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المؤهل العلمي

  • زميل ما بعد الدكتوراه ومستشارة -معهد هارفارد للطب، بريجهام ومستشفى المرأة / كلية الطب في جامعة هارفارد (2004 -2010)
  • دكتوراه في البيولوجيا الخلوية والجزيئية -جامعة باريس الخامسة -رينيه ديكارت، باريس، فرنسا (ديسمبر 2003)
  • ماجستير في البيولوجيا الخلوية والجزيئية -جامعة باريس -رينيه ديكارت، باريس، فرنسا (1998)
  • بكالوريوس في الكيمياء الحيوية -جامعة باريس -رينيه ديكارت، باريس، فرنسا (1994 -1997)

الجوائز والتكريمات

  • Nominee, KAUST Distinguished Teaching Award, 2023 

  • Travel Grant, International Society for Experimental Hematology (ISEH), Tokyo, 2001 

  • Award, Association Nouvelle Recherche Biologique (ANRB), 1999 

  • Fellowship, Association Recherche contre le Cancer (ARC), 1999–2002 

مؤلفات مختارة

  • Gadhoum, S.Z., Merzaban, J.S., & Sackstein, R. Glycan engineering of human CD34+ stem cells enhances their ability to home and reconstitute marrow ablated mice. In preparation. 

  • Gadhoum, S.Z., & Merzaban, J.S. Anti-CD44 antibodies inhibit both mTORC1 and mTORC2: a new rationale for CD44-induced AML therapy. Leukemia. 2016; 30(12):2397–2401. 

  • Abu Samra, D.B., Al-Kilani, A., Hamdan, S.M., Sakashita, K., Gadhoum, S.Z., & Merzaban, J.S. Quantitative characterization of E-selectin interaction with native CD44 and PSGL-1 using a real-time immunoprecipitation-based binding assay. J. Biol. Chem. 2015; 290(35):21213–30. 

  • Aouida, M., Eid, A., Ali, Z., Cradick, T., Lee, C., Deshmukh, H., Atef, A., AbuSamra, D., Gadhoum, S.Z., Merzaban, J., Bao, G., & Mahfouz, M. Efficient fdCas9 synthetic endonuclease with improved specificity for precise genome engineering. PLoS One. 2015; 10(7):e0133373 

  • Merzaban, J.S., Burdick, M.M., Gadhoum, S.Z., Dagia, N.M., Chu, J.T., Fuhlbrigge, R.C., & Sackstein, R. Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells. Blood. 2011; 118(7):1774–83. 

  • Gadhoum, S.Z., & Sackstein, R. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity. Nat. Chem. Biol. 2008; 4(12):751–7. 

  • Delaunay, J., Lecomte, N., Bourcier, S., Qi, J., Gadhoum, Z., Durand, L., Chomienne, C., Robert-Lézénès, J., & Smadja-Joffe, F. Contribution of GM-CSF and IL-8 to the CD44-induced differentiation of acute monoblastic leukemia. Leukemia. 2008; 22(4):873–6. 

  • Dagia, N.M., Gadhoum, S.Z., Knoblauch, C.A., Spencer, J.A., Zamiri, P., Lin, C.P., & Sackstein, R. G-CSF induces E-selectin ligand expression on human myeloid cells. Nat. Med. 2006; 12(10):1185–90. 

  • Maquarre, E., Artus, C., Gadhoum, Z., Jasmin, C., Smadja-Joffe, F., & Robert-Lézénès, J. CD44 ligation induces apoptosis via caspase- and serine protease-dependent pathways in acute promyelocytic leukemia cells. Leukemia. 2005; 19(12):2296–303. 

  • Gadhoum, Z., Leibovitch, M.P., Qi, J., Dumenil, D., Durand, L., Leibovitch, S., & Smadja-Joffe, F. CD44: a new means to inhibit acute myeloid leukemia cell proliferation via p27Kip1. Blood. 2004; 103(3):1059–68 

  • Charrad, R.S., Gadhoum, Z., Qi, J., Glachant, A., Allouche, M., Jasmin, C., Chomienne, C., & Smadja-Joffe, F. Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines. Blood. 2002; 99(1):290–99. 

  • Smadja-Joffe, F., Legras, S., Charrad, S., Gadhoum, Z., & Lesveque, J.P. CD44 et hématopoïèse. Hématologie. 1999; 4:339–49. (in French) 

  • Gadhoum, Z., Delaunay, J., Maquarre, E., Durand, L., Lancereaux, V., Qi, J., Robert-Lezénès, J., Chomienne, C., & Smadja-Joffe, F. The effect of anti-CD44 monoclonal antibodies on differentiation and proliferation of human acute myeloid leukemia cells. Leuk. Lymphoma. 2004; 45(8):1501–10.