Professor Liberale has devoted his career to advancing the frontiers of optical imaging and photonic microfabrication for biomedical and environmental applications. His research focuses on label-free chemical imaging, particularly through coherent Raman scattering techniques, which enable nondestructive, high-resolution visualization of molecular composition in complex samples. These methods are instrumental in investigating cellular biochemistry and have been applied by his group not only in disease diagnostics but also to assess environmental pollution, such as detecting and characterizing microplastics and microfibers. 

His group also pioneers the development of miniaturized photonic systems using high-resolution two-photon lithography. By printing micro-optical elements directly onto optical fiber facets, his team creates compact, multifunctional devices for beam shaping, optical manipulation, and in vivo imaging — extending the reach of photonic technologies to previously inaccessible environments. 

Through the synergistic integration of nonlinear optics, microscale engineering, and chemical imaging, Professor Liberale’s research contributes to the development of next-generation optical tools aimed at improving diagnostics, monitoring environmental contaminants, and deepening our understanding of biological and ecological systems.