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Satoshi Habuchi

Associate Professor, Bioscience

Biological and Environmental Science and Engineering Division


Affiliations

Education Profile

  • ​​​​​​Postdoctoral Fellow, Harvard Medical School, 2005
  • Postdoctoral Fellow, Katholieke Universiteit Leuven, 2001
  • Ph.D., Hokkaido University, 2001
  • M.Sc., Hokkaido University, 1999
  • B.Sc., Hokkaido University, 1997

Research Interests

Professor Habuchi's research focuses on the development of tools and materials for fluorescence molecular imaging. His research interests include the development of microfluidics-based super-resolution/single-molecule fluorescence imaging platform for studying cellular interactions in the presence of external force, development of near-infrared/short wavelength infrared fluorescent nanoparticles using conjugated polymers for single-molecule/particle fluorescence imaging in biological tissues, and development of new single-molecule tracking methods to capture hidden nonrandom motion and conformational dynamics at the molecular level.

Selected Publications

  • AbuZineh, K.; Joudeh, L. I.; Al Alwan, B.; Hamdan, S. M.; Merzaban, J. S.; Habuchi, S. "Microfluidics-based super-resolution microscopy enables nanoscopic characterization of blood stem-cell homing", Sci. Adv. 2018, 4, eaat5304.
  • Abadi, M.; Serag, M. F.; Habuchi, S. "Entangle polymer dynamics beyond reptation", Nat. Commun., 2018, 9, 5098.
  • Piwonski, H.; Michinobu, T.; Habuchi, S. “Controlling photophysical properties of ultrasmall conjugated polymer nanoparticles through polymer chain packing”, Nat. Commun., 2017, 8, 15256.
  • Serag, M. F.; Habuchi, S. “Conserved linear dynamics of single-molecule Brownian motion”, Nat. Commun., 2017, 8, 15675.
  • Serag, M. F.; Abadi, M.; Habuchi, S. “Single-molecule diffusion and conformational dynamics by spatial integration of temporal fluctuations”, Nat. Commun., 2014, 5, 5123.
  • Loveland, A. B.; Habuhi, S.; Walter, J. C.; van Oijen, A. M. “A general approach to break the concentration barrier in single-molecule imaging”, Nat. Methods, 2012, 9, 987-992.
  • Habuchi, S.; Ando, R.; Dedecker, P.; Verheijen, W.; Mizuno, H.; Miyawaki, A.; Hofkens, J. “Reversible single-molecule photoswitcing in the GFP-like fluorescent protein Dronpa”, Proc. Natl. Acad. Sic. USA, 2005, 102, 9511-9516.
  • Abadi, M.; Serag, M. F.; Habuchi, S. "Entangle polymer dynamics beyond reptation", Nat. Commun., 2018, 9, 5098.
  • AbuZineh, K.; Joudeh, L. I.; Al Alwan, B.; Hamdan, S. M.; Merzaban, J. S.; Habuchi, S. "Microfluidics-based super-resolution microscopy enables nanoscopic characterization of blood stem-cell homing", Sci. Adv. 2018, 4, eaat5304.