Affiliations

• Bioscience

Education Profile

• Postdoctoral Fellow, Harvard Medical School, 2005
• Postdoctoral Fellow, Katholieke Universiteit Leuven, 2001Ph.D., Hokkaido University, 2001M.Sc., Hokkaido University, 1999B.Sc., Hokkaido University, 1997

Research Interests

Professor Habuchi's research focuses on the development of tools and materials for fluorescence molecular imaging. His research interests include the development of microfluidics-based super-resolution/single-molecule fluorescence imaging platform for studying cellular interactions in the presence of external force, development of near-infrared/short wavelength infrared fluorescent nanoparticles using conjugated polymers for single-molecule/particle fluorescence imaging in biological tissues, and development of new single-molecule tracking methods to capture hidden nonrandom motion and conformational dynamics at the molecular level.

Selected Publications

• AbuZineh, K.; Joudeh, L. I.; Al Alwan, B.; Hamdan, S. M.; Merzaban, J. S.; Habuchi, S. "Microfluidics-based super-resolution microscopy enables nanoscopic characterization of blood stem-cell homing", Sci. Adv. 2018, 4, eaat5304.
• Abadi, M.; Serag, M. F.; Habuchi, S. "Entangle polymer dynamics beyond reptation", Nat. Commun., 2018, 9, 5098.
• Piwonski, H.; Michinobu, T.; Habuchi, S. “Controlling photophysical properties of ultrasmall conjugated polymer nanoparticles through polymer chain packing”, Nat. Commun., 2017, 8, 15256.
• Serag, M. F.; Habuchi, S. “Conserved linear dynamics of single-molecule Brownian motion”, Nat. Commun., 2017, 8, 15675.
• Serag, M. F.; Abadi, M.; Habuchi, S. “Single-molecule diffusion and conformational dynamics by spatial integration of temporal fluctuations”, Nat. Commun., 2014, 5, 5123.
• Loveland, A. B.; Habuhi, S.; Walter, J. C.; van Oijen, A. M. “A general approach to break the concentration barrier in single-molecule imaging”, Nat. Methods, 2012, 9, 987-992.
• Habuchi, S.; Ando, R.; Dedecker, P.; Verheijen, W.; Mizuno, H.; Miyawaki, A.; Hofkens, J. “Reversible single-molecule photoswitcing in the GFP-like fluorescent protein Dronpa”, Proc. Natl. Acad. Sic. USA, 2005, 102, 9511-9516.
• Abadi, M.; Serag, M. F.; Habuchi, S. "Entangle polymer dynamics beyond reptation", Nat. Commun., 2018, 9, 5098.
• AbuZineh, K.; Joudeh, L. I.; Al Alwan, B.; Hamdan, S. M.; Merzaban, J. S.; Habuchi, S. "Microfluidics-based super-resolution microscopy enables nanoscopic characterization of blood stem-cell homing", Sci. Adv. 2018, 4, eaat5304.