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Samah Zeineb Gadhoum

Lecturer, BESE

Biological and Environmental Science and Engineering Division


Education Profile

  • Post-doctoral Fellow and Advisor - Harvard Institute of Medicine, Brigham and Woman's Hospital/Harvard Medical School. (2004-2010)
  • Doctor of Philosophy in Cellular and Molecular Biology - Université Paris V - René Descartes, Paris, France and INSERM U268, Villejuif, France & INSERM EMI0003, Paris, France (Dec 2003)
  • Master in Cellular and Molecular Biology - Université Paris V - René Descartes, Paris, France and INSERM U268, Villejuif, France (1998)
  • Bachelor of Science in Biochemistry - Université Paris VI - Pierre and Marie Curie, Paris, France (1994-1997)

Selected Publications

Research Articles:

  • Gadhoum SZ, Merzaban JS, and Sackstein R. Glycan Engineering of human CD34+ stem cells enhances their ability to home and reconstitute marrow ablated mice. In preparation.
  • Gadhoum SZ and Merzaban JS. Anti-CD44 antibodies inhibit both mTORC1 and mTORC2: a new rationale for CD44-induced AML therapy. Leukemia. 2016, 30(12):2397-2401.
  • Abu Samra DB, Al-Kilani A, Hamdan SM, Sakashita K, Gadhoum SZ and Merzaban JS­. Quantitative Characterization of E-selectin Interaction with Native CD44 and PSGL-1 using a Real-time Immunoprecipitation-based Binding Assay. JBC. 2015, 290 (35):21213-30.
  • Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering. Aouida M, Eid A, Ali Z, Cradick T, Lee C, Deshmukh H, Atef A, AbuSamra D, Gadhoum SZ, Merzaban J, Bao G, Mahfouz M. PLoS One. 2015, 10(7):e0133373.
  • Merzaban JS, Burdick MM, Gadhoum SZ, Dagia NM, Chu JT, Fuhlbrigge RC, and Sackstein R. Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells. Blood. 2011, 118(7): 1774-1783.
  • Gadhoum SZ, Sackstein R. 2008. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity. Nat Chem Biol, 4(12):751-7.
  • Delaunay J, Lecomte N, Bourcier S, Qi J, Gadhoum Z, Durand L, Chomienne C, Robert-Lézénès J, Smadja-Joffe F. 2008. Contribution of GM-CSF and IL-8 to the CD44-induced differentiation of acute monoblastic leukemia. Leukemia, 22(4):873 -6.
  • Dagia NM, Gadhoum SZ, Knoblauch CA, Spencer JA, Zamiri P, Lin CP, Sackstein R. 2006. G-CSF induces E-selectin ligand expression on human myeloid cells. Nat Med, 12(10):1185-90.
  • Maquarre E, Artus C, Gadhoum Z, Claude Jasmin, Florence Smadja-Joffe and Jacqueline Robert-Lézénès. 2005. CD44 ligation induces apoptosis via caspase- and serine protease-dependent pathways in acute promyelocytic leukemia cells, 19(12):2296-303.
  • Gadhoum Z, Leibovitch MP, Qi J, Dumenil D, Durand L, Leibovitch S, Smadja-Joffe F. 2004. CD44: a new means to inhibit acute myeloid leukemia cell proliferation via p27Kip1. Blood, 103(3):1059-68.
  • Charrad RS, Gadhoum Z, Qi J, Glachant A, Allouche M, Jasmin C, Chomienne C, Smadja-Joffe F. 2002. Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines. Blood: 99(1):290-299.

Reviews:

  • Smadja-Joffe F, Legras S, Charrad S, Gadhoum Z, Lesveque JP. 1999. « CD44 et Hematopoïèse » (review in French) Hématologie 4: 339-349.
  • Gadhoum Z, Delaunay J, Maquarre E, Durand L, Lancereaux V, Qi J, Robert-Lezenes J, Chomienne C, Smadja-Joffe F. 2004. Leuk Lymphoma. The effect of anti-CD44 monoclonal antibodies on differentiation and proliferation of human acute myeloid leukemia cells. 45(8):1501-10.

Thesis:

  1. Gadhoum SZ. Mechanism of Inhibition of proliferation induced by CD44 ligation in acute myeloid leukemic cells. Rene Descartes University. Paris, France. 2003. (in French).

Dissertation:

Gadhoum SZ. "Différenciation des cellules leucémiques aigues par le CD44: études des voies de signalisation". 1998. (in French)