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Nouf Laqtom

Assistant Professor, Bioscience

Biological and Environmental Science and Engineering Division 
Center membership :
Smart Health Initiative

nouf.laqtom@kaust.edu.sa
The Laqtom lab


Affiliations

Education Profile

  • Postdoctoral Fellow, Department of Chemical Engineering, Stanford University, 2022
  • Postdoctoral Fellow, Department of Biology, Whitehead Institute-Massachusetts Institute of Technology, 2019
  • Lecturer, Division of Genomics and Biotechnology, King Abdulaziz University, 2016
  • M.Sc. and Ph.D. in Genomics and Pathway Biology, University of Edinburgh, 2013

Research Interests

Our research interests span from subcellular metabolism to the mechanism of inherited metabolic disease. We aim to 1) discover how a defective lysosome or ER-resident protein contributes to the development of metabolic diseases such as Batten disease 2) Develop molecular tools that allow us to provide cutting-edge knowledge on the ER metabolic composition and better understand their metabolic homeostasis 3) demonstrate novel ER-lysosome contact sites and their functions in cellular homeostasis and 4) develop novel therapeutic strategies and biomarkers for these metabolic diseases. Our experiments are conducted in vivo and in cell culture using several subcellular omics, high-throughput functional genomics, and biochemical techniques.

Selected Publications

  • Laqtom NN. 2023. Studying lysosomal function and dysfunction using LysoIP. Nat Rev Mol Cell Biol. doi.org/10.1038/s41580-023-00619-6

  • Laqtom NN, Dong W, Medoh UN, Cangelosi AL, Dharamdasani V, Chan SH, Kunchok T, Lewis CA, Heinze I, Tang R, Grimm C, Do AND, Porter FD, Ori A, Sabatini DM, AbuRemaileh M. 2022. CLN3 is required for the clearance of glycerophosphodiesters from lysosomes. Nature. 609, 1005–11. doi.10.1038/s41586-022-05221-y

  • Armenta D, Laqtom NN1, Alchemy G, Dong W, Morrow D, Alchemy G, Poltorack C, Nathanson D, Abu-Remalieh M, Dixon SJ. 2022. Ferroptosis inhibition by lysosomal protein catabolism. Cell Chem Biol. 24:S2451-9456(22)00360-9. doi: 10.1016/j.chembiol.2022.10.006.

  • Pedram K, Laqtom NN, Shon DJ, Di Spiezio A, Riley NM, Saftig P, Abu-Remaileh M, Bertozzi, CR. 2022. Discovery of a pathway for endogenous mucin glycodomain catabolism in mammals. PNAS. 119(39):e2117105119.