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Niveen M. Khashab

Associate Professor, Chemical Science

Physical Science and Engineering Division
Center membership : 
Advanced Membranes and Porous Materials


Smart Hybrid Materials (SHMs)

Affiliations

Education Profile

  • ​​​​​Ph.D. University of Florida, 2006
  • B.S. American University of Beirut, 2002

Research Interests


Professor Khashab's research interests are in design, synthesis, and applications of "smart" programmable nanomaterials with emphasis on the controlled release and delivery aspects of the systems. These engineered materials are utilized for biomedical (delivery, sensing, and imaging), industrial (nanocomposites) and environmental (membranes synthesis) applications.

Biomedical Applications
Stimuli responsive nanomaterials are prepared to package and deliver drugs directly to diseased cells, which reduce the harm to healthy parts of the body. It also allows for the delivery of hydrophobic drugs that cannot be up taken by cells. The delivery containers range from carbon based materials to inorganic capsules such as silica nanoparticles. Sensors and imaging agents based on metallic clusters and particles are also designed for separate use or direct incorporation with the delivery system for enhanced theranostic effect.

Industrial Applications
Surface modification of nanomaterials affects many of their physical and chemical properties. Improving the dispersion and interaction of nanomaterials is a hot topic as it has direct industrial application especially in the field of nanocompsites. Interaction of functionalized nanomaterials with different polymer matrices leads to a new generation of thermally, mechanically, and/or electrically enhanced materials.

Environmental Applications
Designing nanomaterial support systems for different catalysts has impressive environmental implications as it boosts the recyclability of these catalysts, which eventually leads to “green” practices. It also increases and protects the activity of the catalysts, which makes this process commercially viable. Furthermore, incorporating the designed nanomaterials in membranes promotes their practical use for different environmental processes.

Selected Publications

  • Li, S.; Moosa, B. A.; Croissant, J. G.; Khashab, N. M. Electrostatic Assembly/Disassembly of Nanoscaled Colloidosomes for Light-Triggered Cargo Release.  Angew. Chem., Int. Ed. 2015, 54, 6804-6808
  • Lee, I. J.; Patil, S.; Fhayli, K.; Alsaiari, S.;  Khashab, N. M. Probing Structural Changes of Self Assembled i-Motif DNA. Chem. Commun. (Cambridge, U. K.) 2015, 51, 3747-3749
  • Song, H.-M.; Zink, J. I.; Khashab, N. M. Investigating Unexpected Magnetism of Mesoporous Silica-Supported Pd and PdO Nanoparticles. Chem. Mater. 2015, 27, 29-36
  • Croissant, J. G.; Cattoen, X.; Wong Chi Man, M.; Durand, J.-O.; Khashab, N. M. Syntheses and Applications of Periodic Mesoporous Organosilica Nanoparticles. Nanoscale 2015, 7, 20318-20334.
  • Fatieiev, Y.; Croissant, J.; Alsaiari, S.; Moosa, B. A.; Anjum, D. H.; Khashab, N. M. Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery. ACS Appl. Mater. Interfaces 2015, 7, 24993-24997.
  • Patil, S.; Moosa, B.; Alsaiari, S.; Alamoudi, K.; Alshamsan, A.; Almailk, A.; Adil, K.; Eddaoudi, M.; Khashab, N. Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery. Chem. - Eur. J. 2016, 22, 13789–13793.
  • Croissant, J. G.; Zhang, D.; Alsaiari, S.; Lu, J.; Deng, L.; Tamanoi, F.; Zink, J. I.; Khashab, N. M. Protein-Gold Clusters-Capped Mesoporous Silica Nanoparticles for High Drug Loading, Autonomous Gemcitabine/Doxorubicin Co-Delivery, and In-Vivo Tumor Imaging. J. Controlled Release 2016, 229, 183-191.​