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Mo Li

Associate Professor, Bioscience

Biological and Environmental Science and Engineering Division

mo.li@kaust.edu.sa


Affiliations

Education Profile

  • Postdoctoral Fellow, Salk Institute for Biological Sciences, 2009
  • Ph.D., University of Georgia, 2007
  • B.Sc., Peking (Beijing) University, 2001

Research Interests

​Professor Li‘s research attempts to understand the molecular basis of the regenerative mechanisms that maintain the proper form and function of the human body. His research programs build on a multidisciplinary platform that integrates stem cell models with genome engineering, functional genomics, bioengineering and chemical screening to gain a holistic understanding of regeneration in its broadest sense, while keeping a commitment to fulfilling the translational promise of stem cell research.

Selected Publications

  • Bi, C.; Yuan, B.; Zhang, Y.; Wang, M.; Tian, Y.; Li, M.*, Prevalent integration of genomic repetitive and regulatory elements and donor sequences at CRISPR-Cas9-induced breaks. Communications Biology, Jan 20, 2025.

  • Zhang, Y.; Bi, C.; Nadeef, S.; Maddirevula S.; Alqahtani, M.; Alkuraya, F.*; Li, M.*, NanoRanger enables rapid single base-pair resolution of genomic disorders. Med, July 23, 2024

  • Yuan, B.; Bi, C.; Tian, Y.; Wang, J.; Jin, Y.; Alsayegh, K.; Tehseen, M.; Yi, G.; Zhou, X;, Shao, Y.; Romero, F.; Fischle, W.; Izpisua Belmonte, J.C.; Hamdan, S.; Huang, Y.; Li, M.*, Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks. BMC Biology, Apr 29, 2024.

  • Chandrasekaran, A.P. and Li M., Extra (embryonic) dialogues: keys to improved stem cell-based embryo models. Cell Stem Cell, Feb 1, 2024

  • Bi, C.; Wang, L.; Fan, Y.; Yuan, B.; Ramos-Mandujano, G.; Zhang, Y.; Alsolami, S.; Wang, J.; Shao, Y.; Reddy, P.; Zhang, P.-Y.; Huang, Y.; Yu, Y.*; Izpisua Belmonte, J.C.*; Li, M.*, Single-cell Individual Full-length mtDNA Sequencing Uncovers Unexpected Heteroplasmy Shifts in mtDNA Editing. Nucleic Acids Research, Mar 31, 2023.

  • Bi, C.; Wang, L.; Fan, Y.; Yuan, B.; Alsolami, S.; Zhang, Y.; Zhou, X.; Zhang, P.-Y.; Huang, Y.; Yu, Y.*; Izpisua Belmonte, J.C.*; Li, M.*, Quantitative Haplotype-resolved Analysis of mtDNA Heteroplasmy in Human Single Oocytes, Blastoids, and Pluripotent Stem Cells, Nucleic Acids Research, April 4, 2023.

  • Yuan, B.; Zhou, X.; Suzuki K.; Ramos-Mandujano, G.; Wang, M.; Tehseen, M.; Cortes-Medina, L.; Moresco, J. J.; Dunn, S.; Hernandez-Benitez, R.; Hishida, T.; Kim, N.Y.; Andijani, M. M.; Bi, C.; Ku, M.; Takahashi, Y.; Xu, J.; Qiu, J.; Huang, L.; Benner, C.; Aizawa, E.; Qu, J.; Liu, G.H.; Li, Z.; Yi, F.; Ghosheh, Y.; Shao, C.; Shokhirev, M.; Comoli, P.; Frassoni, F.; Yates, R. J. III; Fu, XD; Rodríguez Esteban, C; Hamdan, S.; Izpisua Belmonte, J.C.*; Li M.*, Wiskott-Aldrich Syndrome Protein Forms Nuclear Condensates and Regulates Alternative Splicing. Nature Communications, Jun 25, 2022

  • Klein, S. G. §; Alsolami, S. M. §; Arossa, S.; Ramos Mandujano, G.; Parry, A. J.; Steckbauer, A.; Duarte, C. M.*; Li, M.*, In situ monitoring reveals cellular environmental instabilities in human pluripotent stem cell culture. Communications Biology, 2022, 5, 119. § equal contribution.

  • Fan, Y. §; Min, Z. §; Alsolami, S. M. §; Ma, Z.; Zhang, E.; Chen, W.; Zhong, K.; Pei, W.; Kang, X.; Zhang, P.; Wang, Y.; Zhang, Y.; Zhan, L.; Zhu, H.; An, C.; Li, R.; Qiao, J.; Tan, T.*;, Li, M.*; Yu, Y.*, Generation of human blastocyst-like structures from pluripotent stem cells. Cell Discovery, 2021, 7:81. § equal contribution.

  • Klein, S. G. §; Alsolami, S. M. §; Steckbauer, A.; Arossa, S.; Parry, A. J.; Ramos Mandujano, G.; Alsayegh, K.; Izpisua Belmonte, J. C.*; Li, M.*; Duarte, C. M.*, A prevalent neglect of environmental control in mammalian cell culture calls for best practices. Nature Biomedical Engineering, 2021, 1-6. § equal contribution.