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Affiliations

• Bioscience
• Bioengineering

Education Profile

• ​​​​​​​​​​PhD, University of Warsaw, Poland, 2012
• MSc, University of Wroclaw, Poland, 2008

Research Interests

Research in Professor Łukasz Jaremko's Molecular Diagnostics and Drug Discovery (MD3) group focuses on atomic-level insight into essential and topical questions from biochemistry and medicine, such as, e.g., the primary molecular bases of cancer, including leukaemia and lung cancer (Nature, 2021). The team is actively working in the field of targeted drug design and discovery, using structure-dynamics analysis to search for small molecules (ligands) that interact specifically with the disease-associated proteins. Identified lead compounds are then engineered to increase their binding and, thus therapeutic potency against cancer (Nature Chem Biol, 2021). Biomolecular nuclear magnetic resonance (NMR) spectroscopy is the crucial experimental technique used and refined (J Chem Phys B, 2015; Angewandte Chem, 2016; J Biomol NMR, 2018, 2020) to tackle challenging macromolecular assemblies (Nature Chem Biol, 2013, 2021; Science, 2014; Nature Communications, 2016, 2017; Nucleic Acids Res, 2019; Am J Hum Genetics, 2019; Chemical Science, 2020; eLife, 2021; Nature 2021; Mol. Cell 2021). These NMR-based structural studies are then combined with molecular and enzymatic assays as well as other state-of-the-art biophysical techniques such as X-ray crystallography, electron microscopy, circular dichroism and molecular dynamics simulations to get further insights into the complex biological systems essential for human health.

Selected Publications

• Kharchenko, V.; Linhares, B. M.; Borregard, M.; Czaban, I.; Grembecka, J.; Jaremko, M.; Cierpicki, T.*; Jaremko, Ł.*,
  Increased protein dynamics defines ligandability of BTB domains,
  Under Review.

• Mandal, P.; Yerkesh, Z.; Kharchenko, V.; Zandarashvili, L.; Bensaddek, D.; Jaremko, Ł.; Black, B.E.; Fischle, W.,
  Molecular basis of UHRF1 allosteric activation for synergistic histone modification binding by PI5P,
  Under Review.

• Sengupta, D.; Zeng, L.; Li, Y.; Hausmann, S.; Ghosh, D.; Yuan, G.; Nguyen, T. N.; Lyu, R.; Caporicci, M.; Benitez, A. M.; Coles, G. L.; Kharchenko, V.; Czaban, I.; Azhibek, D.; Fischle, W.; Jaremko, M.; Wistuba, I. I.; Sage, J.; Jaremko, Ł.; Li, W.; Mazur, P. K.; Gozani, O.,
  NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis,
  Molecular Cell 2021, 81, 4481–4492.e9.
  

• Chen, K.; Lyskowski, A.; Jaremko, Ł.*; Jaremko, M.*,
  Genetic and molecular factors determining grain weight in rice,
  Front Plant Sci 2021, 12, 605799.
  

• Chandra, K., Al-Harthi, S., Almulhim, F., Emwas, A.-H., Jaremko, Ł.*, Jaremko, M.,
  The robust NMR Toolbox for Metabolomics,
  Mol. Omics RSC 2021, 17, 719–724.
  

• Shukla, S.; Ying, W.; Gray, F.; Yao, Y.; Simes, M. L.; Zhao, Q.; Miao, H.; Cho, H. J.; González-Alonso, P.; Winkler, A.; Lund, G.; Purohit, T.; Kim, E. G.; Zhang, X.; Ray, J. M.; He, S.; Nikolaidis, C.; Ndoj, J.; Wang, J.; Jaremko, Ł.; Jaremko, M.; Ryan, R.; Guzman, M. L.; Grembecka, J.; Cierpicki, T.,
  Small molecule inhibitors targeting Polycomb Repressive Complex 1 RING domain,
  Nat. Chem. Biol. 2021, 17, 784–793.
  

• Zhao, X.; Hameed, U. F. S.; Kharchenko, V.; Liao, C.; Huser, F.; Remington, J. M.; Radhakrishnan, A. K.; Jaremko, M.; Jaremko, Ł.*; Arold, S.* T., Li, J.*,
  Molecular basis for the adaptive evolution of environment sensing by H-NS proteins.
  Elife 2021, 10, e57467.

• Yuan, G.; Flores, N. M.; Hausmann, S.; Lofgren, S. M.; Kharchenko, V.; Angulo-Ibanez, M.; Sengupta, D.; Lu, X. Y.; Czaban, I.; Azhibek, D.; Vicent, S.; Fischle, W.; Jaremko, M.; Fang, B. L.; Wistuba, I. I.; Chua, K. F.; Roth, J. A.; Minna, J. D.; Shao, N. Y.; Jaremko, Ł.*; Mazur, P. K.*; Gozani, O.*
  Elevated NSD3 histone methylation activity drives squamous cell lung cancer.
  Nature 2021, 590 (7846), 504-508.

• Chandra, K.; Al-Harthi, S.; Sukumaran, S.; Almulhim, F.; Emwas, A.-H.; Atreya, H. S.; Jaremko, Ł.*; Jaremko, M.*,
  NMR-based metabolomics with enhanced sensitivity.
  RSC Adv 2021, 11 (15), 8694-8700.
  

• Pelaz, D. A.; Yerkesh, Z.; Kirchgassner, S.; Mahler, H.; Kharchenko, V.; Azhibek, D.; Jaremko, M.; Mootz, H. D.; Jaremko, Ł.; Schwarzer, D.; Fischle, W.,
  Examining histone modification crosstalk using immobilized libraries established from ligation-ready nucleosomes.
  Chem Sci 2020, 11, 9218-9225.
  

• Kharchenko, V.; Nowakowski, M.; Jaremko, M.; Ejchart, A.; Jaremko, Ł.*,
  Dynamic ¹⁵N{¹H} NOE measurements: a tool for studying protein dynamics.
  J Biomol NMR 2020, 74, 707–716.
  

• Duarte, C. M.; Jaremko, M.; Jaremko, Ł.,
  Potentially systemic impacts of elevated CO₂ on the human proteome and health.
  Front Public Health 2020, 8, 645.
  

• Alam, I.; Kamau, A. A.; Kulmanov, M.; Jaremko, Ł.; Arold, S. T.; Pain, A.; Gojobori, T.; Duarte, C. M.,
  Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2.
  Front Cell Infect Mi 2020, 10, 405.
  

• Shahul Hameed, U. F.; Liao, C.; Radhakrishnan, A. K.; Huser, F.; Aljedani, S. S.; Zhao, X.; Momin, A. A.; Melo, F. A.; Guo, X.; Brooks, C., Li, Y.; Cui, X.; Gao, X.; Ladbury, J. E.; Jaremko, Ł.; Jaremko, M.; Li, J.; Arold, S.T.,
  H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing.
  Nucleic Acids Res 2019, 47 (5), 2666-2680.
  

• Al-Harthi, S.; Lachowicz, J. I.; Nowakowski, M. E.; Jaremko, M.; Jaremko, Ł.*,
  Towards the functional high-resolution coordination chemistry of blood plasma human serum albumin.
  J Inorg Biochem 2019, 198, 110716.
  

• Jaremko, Ł.; Jaremko, M.; Ejchart, A.; Nowakowski, M.,
  Fast evaluation of protein dynamics from deficient ¹⁵N relaxation data.
  J Biomol NMR 2018, 70 (4), 219-228.

*co/correspondoing author.