The Al Qureshah Lab investigates the genetic, cellular, and molecular underpinnings of life-threatening viral diseases caused by inborn errors of immunity (IEIs). Using an integrated approach that combines human genetics, immunology, and molecular biology, the lab studies how single-gene defects disrupt interferon-mediated antiviral responses and shape host susceptibility to infection. The Al Qureshah Lab applies genomic analyses, cellular and molecular immunology, and in vivo modeling to dissect the mechanisms governing innate and adaptive antiviral immunity. Building on these mechanistic insights, the lab also explores and develops innovative diagnostic and therapeutic strategies for individuals vulnerable to severe viral infections, translating fundamental discoveries into precision medicine applications. Collectively, Dr. Al Qureshah’s research aims to contribute to the development of next-generation antiviral therapies and personalized interventions that enhance human health and resilience against emerging infectious threats.