Prof. Liberale's research interests are focused on developing and applying label-free chemical imaging techniques based on vibrational spectroscopy (Infrared and Raman micro-spectroscopy) and multi-photon processes (Coherent Raman Microscopy, SHG). One of the main aims of this research activity is to unveil specific bio-chemical signatures of cancer stem cells, with a particular focus on understanding the dysregulation of their lipid metabolism.
He is also interested on using high-resolution 3D printing based on Direct Laser Writing for the fabrication of novel micro-optics, towards the miniaturization of complex optical systems, and of smart micro-/nano-structures to be used as a probe in nanoscale imaging. This research activity takes advantage from an integrated approach that combines design, micro/nanofabrication and optical techniques.
Extended field-of-view ultrathin microendoscopes for high-resolution two-photon imaging with minimal invasiveness A Antonini, A Sattin, M Moroni, S Bovetti, C Moretti, F Succol, A Forli, D Vecchia, V P Rajamanickam, A Bertoncini, S Panzeri, C Liberale, T Fellin, eLife 9:e58882 (2020)
3D printed waveguides based on Photonic Crystal Fiber designs for complex fiber-end photonic devices, A Bertoncini, C Liberale, Optica 7 (11), 1487-1494 (2020)
Fingerprint‐to‐CH stretch continuously tunable high spectral resolution Stimulated Raman Scattering microscope, S P Laptenok, V P Rajamanickam, L Genchi, T Monfort , Y Lee, I I Patel, A Bertoncini, C Liberale, Journal of Biophotonics 12(9) e201900028 (2019)
Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging, L Tirinato, C Liberale, S Di Franco, P Candeloro, A Benfante, R La Rocca, L Potze, R Marotta, R Ruffilli, V P Rajamanickam, M Malerba, F De Angelis, A Falqui, E Carbone, M Todaro, J Medema, G Stassi, E Di Fabrizio, Stem Cells 33 (1), 35-44 (2015)
Miniaturized all-fibre probe for three-dimensional optical trapping and manipulation, C Liberale, P Minzioni, F Bragheri, F De Angelis, E Di Fabrizio, I Cristiani, Nature Photonics 1 (12), 723-727 (2007)