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Antonio Adamo

Assistant Professor, Bioscience

Biological and Environmental Science and Engineering Division


Affiliations

Education Profile

  • ​​​​​​​FEBS Senior Postdoctoral Fellow, European Institute of Oncology (IEO), Italy, 2012-2015
  • Postdoctoral Fellow, Center of Regenerative Medicine of Barcelona (CMRB), Spain, 2009-2012
  • Ph.D. in Biotechnologies applied to Medical Sciences, University of Milan, 2008
  • M.Sc., Medical Biotechnologies and Molecular Medicine, University of Milan, 2005
  • B.Sc., Medical Biotechnologies, University of Milan, 2003

Research Interests

Professor Adamo's research interests focus on the use of human embryonic stem cells (hESCs) and patient-derived induced pluripotent stem cells (iPSCs) to model the onset and progression of human disorders linked to copy number variations “in a dish.” His team developed the largest cohort of Klinefelter syndrome (karyotype 47,XXY) and high-grade X aneuploid iPSCs (karyotype 48,XXXY and 49,XXXXY) that he uses to study the molecular dysregulations associated with X chromosome aneuploidy during the earliest stages of human development. Professor Adamo’s team combines reprogramming, organoid derivation, and genome editing techniques with a multi-omics approach to identify the transcriptional and epigenetic signatures underlying human diseases.

Selected Publications

  • Astro V, Alowaysi M, Fiacco E, Saera-Vila A, Cardona-Londoño KJ, Aiese Cigliano R, Adamo A: Pseudoautosomal Region 1 Overdosage Affects the Global Transcriptome in iPSCs From Patients With Klinefelter Syndrome and High-Grade X Chromosome Aneuploidies. Frontiers in Cell and Developmental Biology 2021.
  • Astro V., Ramirez-Calderon G., Pennucci R., Caroli J., Saera-Vila A., Cardona-London ̃o K., Forastieri C., Fiacco E., Maksoud F., Alowaysi M., Sogne E., Falqui A., Gonzalez F., Montserrat N., Battaglioli E., Mattevi A., and Adamo A. Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism. iScience 25, July 15, 2022.
  • Fiacco E, Alowaysi M, Astro V, Adamo A: Derivation of two naturally isogenic iPSC lines (KAUSTi006-A and KAUSTi006-B) from a mosaic Klinefelter Syndrome patient (47-XXY/46-XY). Stem Cell Research Volume 49 December 2020.
  • Alowaysi M, Astro V, Fiacco E, Adamo A: Generation of two iPSC lines (KAUSTi001-A, KAUSTi002-A) from a rare high-grade Klinefelter Syndrome patient (49-XXXXY) carrying a balanced translocation t(4,11) (q35,q23). Stem Cell Research Volume 49 December 2020.
  • Adamo A., Atashpaz S., Germain P.-L., Zanella M., D’Agostino G., Albertin V., Chenoweth J., Micale L., Fusco M., Unger C., Augello B., Palumbo O., Hamilton B., Carella M., Donti E., Pruneri G., Selicorni A., Biamino E., Prontera P., McKay R., Merla G. & Testa G. (2015) 7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages. Nature Genetics 2015 Feb;47(2):132-41
  • Adamo A, Barrero MJ, Izpisúa Belmonte JC. (2011) LSD1 and pluripotency: a new player in the network. Cell Cycle 10(19): 3215-6.
  • Adamo A, Sesé B, Boue S, Castaño J, Paramonov I, Barrero MJ, Izpisúa Belmonte JC. (2011) LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells. Nature Cell Biology 13(6): 652-60.