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By investigating how sex chromosomes contribute to differences in susceptibility to human diseases, our research lays the foundation for the development of gender-tailored pharmacological therapies. 

Program Affiliations

Biography

Professor Antonio Adamo earned his B.S., M.S., and Ph.D. in Medical Biotechnologies and Molecular Medicine from the University of Milan, Italy. He completed postdoctoral fellowships at the Center of Regenerative Medicine in Barcelona, Spain, and the European Institute of Oncology in Milan. In February 2016, he joined KAUST, drawn by its state-of-the-art facilities and collaborative research environment. 

Professor Adamo’s research interests focus on use of human embryonic stem cells (hESCs) and patient-derived induced pluripotent stem cells (iPSCs) to model the onset and progression of human disorders linked to sex chromosome aneuploidies “in a dish.” His team combines reprogramming, brain organoid derivation, and genome editing techniques with a multiomics approach to identify the transcriptional and epigenetic signatures underlying human diseases. His lab has developed extensive cohorts of iPSC lines from patients with sex chromosome aneuploidies, including the first Saudi iPSC cohort, to study the molecular dysregulations associated with X and Y chromosomes overdosage. 

Research Interests

Professor Adamo’s laboratory focuses on the use of human embryonic stem cells (hESCs) and patient-derived induced pluripotent stem cells (iPSCs) to model the onset and progression of human disorders linked to copy number variations “in a dish.” His team developed the largest cohort of Klinefelter syndrome (karyotype 47,XXY) and high-grade X aneuploid iPSCs (karyotype 48,XXXY and 49,XXXXY), a unique cellular model that they use to study the molecular dysregulations associated with X chromosome aneuploidy during the earliest stages of human development. 

Keyword tag icon
Brain organoids Disease Modeling iPSCs Klinefelter Syndrome Jacobs Syndrome

Education Profile

  • FEBS Senior Postdoctoral Fellow, European Institute of Oncology (IEO), Italy, 2012-2015

  • Postdoctoral Fellow, Center of Regenerative Medicine of Barcelona (CMRB), Spain, 2009-2012

  • Ph.D. in Biotechnologies applied to Medical Sciences, University of Milan, 2008

  • M.Sc., Medical Biotechnologies and Molecular Medicine, University of Milan, 2005

  • B.Sc., Medical Biotechnologies, University of Milan, 2003

Publications