Professor Alfredo De Biasio leads a research group on the structural dynamics of DNA replication and repair. Prior to joining KAUST in 2021, he held research and teaching appointments at Elettra Sincrotrone Trieste, Italy; CIC bioGUNE, Spain; and the University of Leicester, U.K. His work, employing cryo-electron microscopy to capture dynamic molecular processes at high resolution, has led to publications in high-impact journals including Nature. He holds national habilitations to both Associate and Full Professor in Italy and was recognized as a Young Distinguished Scientist by Elettra Sincrotrone Trieste. 

Professor De Biasio’s research focuses on understanding the structure and function of molecular machines that drive DNA replication and repair. Using cryo-electron microscopy, his work captures dynamic structural changes at high resolution, revealing key mechanisms in genome maintenance. His current projects include studying the human replicative helicase, the Pol δ-PCNA complex, and DNA lesion bypass machinery. Through these studies, Professor De Biasio’s research addresses fundamental questions in genome stability, contributing to advances in molecular biology and biomedicine.