Professor, Bioscience
valerio.orlando@kaust.edu.sa
KAUST Environmental Epigenetics Program
Bodega B, Marasca F, Ranzani V, Cherubini A, Della Valle F, Neguembor MV, Wassef M, Zippo A Lanzuolo C, Pagani M, Orlando V. A cytosolic Ezh1 isoform modulates a PRC2---Ezh1 epigenetic adaptive response in postmitotic cells. Nature Struct Mol Biol. 2017 May;24(5):444
Li M, Borrelli E, Magistretti PJ, Izpisua Belmonte JC, Sassone---Corsi P, Orlando V. Gathering by the Red Sea highlights links between environment and epigenetics. Nature Struct Mol Biol. 2017 Jun 6;24(6):491-493
Marasca F, Bodega B, Orlando V. (2018). How Polycomb mediated cell memory deals with a changing environment. Bioessays Apr;40(4):e170013
Dyar KA, et al Eckel-Mahan K, Sassone-Corsi P. Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks. Cell. 2018 Sep 6;174(6):1571- 1585
Peng Liu, Muhammad Shuaib, Huoming Zhang, Seba S. Nadeef, Valerio Orlando. (2019) Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal dependent PRC2-Ezh1a/b mediated adaptive stress response pathway in skeletal muscle cells. Epigenetics and Chromatin. Dec 19;12(1):78.
Della Valle F, Thimma M, Caiazzo M, Pulcrano, Celii,M, Adroub S, Liu P, Lobato G, Broccoli V, Orlando V. (2020). Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons reactivates LINE-1 repetitive elements. Stem Cell Reports Jan 14;14(1):60- 74
Bonetti A, et al, Gimenez J, et al…Orlando V* and Carninci P*, 2020 (RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions. Nature Communications Feb 24;11(1):1018 (* Co- corresponding authors)
Mangiavacchi A, Liu P, Della Valle F and Orlando V. (2021) New insights on the functional role of retrotranspososns dynamics in mammalian somatic cells. Cell Mol Life Sci. 78(13):5245-5256.
El Said N, Della Valle F et al and Orlando V*(2021) Malat-1- PRC2-EZH1 interaction supports the oxidative stress dependent H3K27me3 remodeling in skeletal myotube. Cell Death and Disease 16;12(10):850.
Fallatah B, Shuaib M, Adroub S, Paytuv-Gallart A, Della Valle F, Nadeef S, Lanzuolo C, Orlando V. (2021). Ago1 controls myogenic differentiation by regulating eRNA mediated CBP guided epigenome reprogramming. Cell Reports 30;37(9):11006
Della Valle F. Reddy P…..Izpisua-Belmonte JC and Orlando V. (2022). L1-RNA is causative of heterochromatin erosion and target for amelioration of senescent phenotypes in progeroid syndromes. Science Translational Medicine doi: 10.1126/scitranslmed.abl6057.
Mangiavacchi A, Morelli G, Orlando V. (2023). Behind the scenes: How RNA orchestrates the epigenetic regulation of gene expression. Front Cell Dev Biol. Jan 25;11:1123975
Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance TraitsInt J Mol Sci. 2022 Feb 25;23(5):2538. doi: 10.3390/ijms23052538.
Ago1 controls myogenic differentiation by regulating eRNA-mediated CBP-guided epigenome reprogramming.Cell Rep . 2021 Nov 30;37(9):110066. doi: 10.1016/j.celrep.2021.110066.
How Polycomb-Mediated Cell Memory Deals With a Changing Environment: Variations in PcG complexes and proteins assortment convey plasticity to epigenetic regulation as a response to environment.Bioessays . 2018 Apr;40(4):e1700137. doi: 10.1002/bies.201700137. Epub 2018 Mar 9.
FANTOM5 CAGE profiles of human and mouse samples.Sci Data . 2017 Aug 29;4:170112. doi: 10.1038/sdata.2017.112.
Gathering by the Red Sea highlights links between environment and epigenetics.Nat Struct Mol Biol .2017 Jun 6;24(6):491-493. doi: 10.1038/nsmb.3422.
A cytosolic Ezh1 isoform modulates a PRC2-Ezh1 epigenetic adaptive response in postmitotic cells.Nat Struct Mol Biol . 2017 May;24(5):444-452. doi: 10.1038/nsmb.3392. Epub 2017 Mar 27
Characterization of piRNAs across postnatal development in mouse brain.Sci Rep . 2016 Apr 26;6:25039. doi: 10.1038/srep25039.
The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome.PLoS Biol . 2015 Dec 18;13(12):e1002315. doi: 10.1371/journal.pbio.1002315. eCollection 2015 Dec.
Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage.PLoS One . 2015 Dec 14;10(12):e0144176. doi: 10.1371/journal.pone.0144176. eCollection 2015.
Discovery of molecular markers to discriminate corneal endothelial cells in the human body.PLoS One . 2015 Mar 25;10(3):e0117581. doi: 10.1371/journal.pone.0117581. eCollection 2015.
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.Science . 2015 Feb 27;347(6225):1010-4. doi: 10.1126/science.1259418. Epub 2015 Feb 12.
The statistical geometry of transcriptome divergence in cell-type evolution and cancer.Nat Commun . 2015 Jan 14;6:6066. doi: 10.1038/ncomms7066.
Repetitive elements dynamics in cell identity programming, maintenance and disease.Curr Opin Cell Biol . 2014 Dec;31:67-73. doi: 10.1016/j.ceb.2014.09.002.
CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes.Sci Rep . 2014 Jun 24;4:5228. doi: 10.1038/srep05228.
Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.Proc Natl Acad Sci U S A . 2014 Apr 8;111(14):5289-94. doi: 10.1073/pnas.1312717110. Epub 2014 Mar 27.
Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells.PLoS One . 2014 Mar 27;9(3):e80274. doi: 10.1371/journal.pone.0080274. eCollection 2014
A promoter-level mammalian expression atlas.Nature . 2014 Mar 27;507(7493):462-70. doi: 10.1038/nature13182.
RNA-interference components are dispensable for transcriptional silencing of the drosophila bithorax-complex.PLoS One . 2013 Jun 13;8(6):e65740. doi: 10.1371/journal.pone.0065740. Print 2013.